Determinants of evolution of endplate and disc degeneration in the lumbar spine: a multifactorial perspective
Degeneration of the intervertebral disc and the endplate of the vertebral body is a complex and multifactorial process, which inevitably disrupts the normal mechanical behaviour of the spine. Endplate bone marrow changes (EC) have been associated with disc degeneration (DD), suggesting that both variables need to be considered when investigating the degenerative process. The aim of the study was to determine associative predictors for the progression of lumbar spine degeneration.
Double lumbar MRI’s were taken within a four-year interval amongst 90 patients in a longitudinal study design.
The variables age, gender, BMI, sacral slope or scoliosis were unable to predict the progression for DD. However, the authors did note a higher lordosis in participants with no progression. Meanwhile, a slightly higher degree of scoliosis was the only factor that was mildly associated with the progression of EC.
These findings suggest that scoliotic deformity and lesser lumbar lordosis are associated with an increased overall degeneration of the lumbar spine. > From: Farshad-Amacker et al., Eur Spine J (2014) (Epub ahead of print). All rights reserved to Springer.
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